Adverse Outcome Pathway and Risks of Anticoagulant Rodenticides to Predatory Wildlife
Identifieur interne : 000339 ( Canada/Analysis ); précédent : 000338; suivant : 000340Adverse Outcome Pathway and Risks of Anticoagulant Rodenticides to Predatory Wildlife
Auteurs : Barnett A. Rattner [États-Unis] ; Rebecca S. Lazarus [États-Unis] ; John E. Elliott [Canada] ; Richard F. Shore [Royaume-Uni] ; Nico Van Den Brink [Pays-Bas]Source :
- Environmental science & technology [ 0013-936X ] ; 2014.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Mortalité, Vie sauvage.
English descriptors
- KwdEn :
Abstract
Despite a long history of successful use, routine application of some anticoagulant rodenticides (ARs) may be at a crossroad due to new regulatory guidelines intended to mitigate risk. An adverse outcome pathway for ARs was developed to identify information gaps and end points to assess the effectiveness of regulations. This framework describes chemical properties of ARs, established macromolecular interactions by inhibition of vitamin K epoxide reductase, cellular responses including altered clotting factor processing and coagulopathy, organ level effects such as hemorrhage, organism responses with linkages to reduced fitness and mortality, and potential consequences to predator populations. Risk assessments have led to restrictions affecting use of some second-generation ARs (SGARs) in North America. While the European regulatory community highlighted significant or unacceptable risk of ARs to nontarget wildlife, use of SGARs in most EU member states remains authorized due to public health concerns and the absence of safe alternatives. For purposes of conservation and restoration of island habitats, SGARs remain a mainstay for eradication of invasive species. There are significant data gaps related to exposure pathways, comparative species sensitivity, consequences of sublethal effects, potential hazards of greater AR residues in genetically resistant prey, effects of low-level exposure to multiple rodenticides, and quantitative data on the magnitude of nontarget wildlife mortality.
Affiliations:
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Pascal:15-0037780Le document en format XML
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There are significant data gaps related to exposure pathways, comparative species sensitivity, consequences of sublethal effects, potential hazards of greater AR residues in genetically resistant prey, effects of low-level exposure to multiple rodenticides, and quantitative data on the magnitude of nontarget wildlife mortality.</div></front></TEI><affiliations><list><country><li>Canada</li><li>Pays-Bas</li><li>Royaume-Uni</li><li>États-Unis</li></country><region><li>Gueldre (province)</li></region><settlement><li>Wageningue</li></settlement><orgName><li>Université de Wageningue</li></orgName></list><tree><country name="États-Unis"><noRegion><name sortKey="Rattner, Barnett A" sort="Rattner, Barnett A" uniqKey="Rattner B" first="Barnett A." last="Rattner">Barnett A. Rattner</name></noRegion><name sortKey="Lazarus, Rebecca S" sort="Lazarus, Rebecca S" uniqKey="Lazarus R" first="Rebecca S." last="Lazarus">Rebecca S. Lazarus</name></country><country name="Canada"><noRegion><name sortKey="Elliott, John E" sort="Elliott, John E" uniqKey="Elliott J" first="John E." last="Elliott">John E. Elliott</name></noRegion></country><country name="Royaume-Uni"><noRegion><name sortKey="Shore, Richard F" sort="Shore, Richard F" uniqKey="Shore R" first="Richard F." last="Shore">Richard F. Shore</name></noRegion></country><country name="Pays-Bas"><region name="Gueldre (province)"><name sortKey="Van Den Brink, Nico" sort="Van Den Brink, Nico" uniqKey="Van Den Brink N" first="Nico" last="Van Den Brink">Nico Van Den Brink</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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